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Chronic elevation of cortisol levels , as seen in Cushing's syndrome, is associated with multiple adverse effects including: Central obesity and metabolic syndrome Insulin resistance and type 2 diabetes Hypertension and cardiovascular disease Osteoporosis and increased fracture risk Mood disturbances, anxiety, and depression Impaired immune function and wound healing Psychological stress can affect cortisol patterns, though the relationship is complex and varies between individuals
PMID: 205 StangerMJThompsonLAYoungAJLiebermanHR
Symptoms are often most noticeable during treatment initiation or dose escalation
Avoid rubbing the site , as this can disperse medication and worsen bruising
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